Manuela Ruzzoli

Research

Associate Group Leader - Ikerbasque Research Fellow 2021-2026 - Ramon y Cajal Fellow 2021-2026

Keywords: Attention, Cognitive Control, (Multisensory) Perception, Electroencephalogram (EEG), Brain Oscillations, Brain Stimulation

Manuela’s research investigates the physiological and cognitive mechanisms associated with human behaviour in perception, attention and cognitive control. She is interested in identifying reliable brain states predictive of performance to foster self-regulation of cognition. To do that, Manuela uses EEG (event-related and ongoing activity) and non-invasive brain stimulation (TMS, tES), coupled with psychophysics, neuropsychology or behavioural tests. Currently, she is leading projects on brain-computer interface (BCI) for attention enhancement with an emphasis on real-time analyses.

Research group: Brain Rhythms and Cognition

m.ruzzoli@bcbl.eu

+34 943 309 300 Ext.: 217

2024

Issa, M.F., Khan, I., Ruzzoli, M., Molinaro, N., & Lizarazu, M. (2024). On the speech envelope in the cortical tracking of speech. NeuroImage, 297. Doi:10.1016/j.neuroimage.2024.120675

Mushtaq, F., Welke, D., Gallagher, A., Pavlov, Y.G., Kouara, L., Bosch-Bayard, J., van den Bosch, J.J.F., Arvaneh, M., Bland, A.R., Chaumon, M., Borck, C., He, X., Luck, S.J., Machizawa, M.G., Pernet, C., Puce, A., Segalowitz, S.J., Rogers, C., Awais, M., Babiloni, C., Bailey, N.W., Baillet, S., Bendall, R.C.A., Brady, D., Bringas-Vega, M.L., Busch, N.A., Calzada-Reyes, A., Chatard, A., Clayson, P.E., Cohen, M.X., Cole, J., Constant, M., Corneyllie, A., Coyle, D., Cruse, D., Delis, I., Delorme, A., Fair, D., Falk, T.H., Gamer, M., Ganis, G., Gloy, K., Gregory, S., Hassall, C.D., Hiley, K.E., Ivry, R.B., Jerbi, K., Jenkins, M., Kaiser, J., Keil, A., Knight, R.T., Kochen, S., Kotchoubey, B., Krigolson, O.E., Langer, N., Liesefeld, H.R., Lippé, S., London, R.E., MacNamara, A., Makeig, S., Marinovic, W., Martínez-Montes, E., Marzuki, A.A., Mathew, R.K., Michel, C., Millán, J.d.R., Mon-Williams, M., Morales-Chacón, L., Naar, R., Nilsonne, G., Niso, G., Nyhus, E., Oostenveld, R., Paul, K., Paulus, W., Pfabigan, D.M., Pourtois, G., Rampp, S., Rausch, M., Robbins, K., Rossini, P.M., Ruzzoli, M., Schmidt, B., Senderecka, M., Srinivasan, N., Stegmann, Y., Thompson, P.M., Valdes-Sosa, M., van der Molen, M.J.W., Veniero, D., Verona, E., Voytek, B., Yao, D., Evans, A.C., & Valdes-Sosa, P. (2024). One hundred years of EEG for brain and behaviour research. Nature Human Behaviour, 8(8), 1437-1443. Doi:10.1038/s41562-024-01941-5

2023

Esparza-Iaizzo, M., Vigué-Guix, I., Ruzzoli, M., Torralba-Cuello, M., & Soto-Faraco, S. (2023). Long-Range ἁ-Synchronization as Control Signal for BCI: A Feasibility Study. eNeuro, 10(3), 1-14. Doi:10.1523/ENEURO.0203-22.2023

2022

Keitel, C., Ruzzoli, M., Dugué, L., Busch, N.A., & Benwell, C.S.Y. (2022). Rhythms in cognition: The evidence revisited. European Journal of Neuroscience, 55(11-12), 2991-3009. Doi:10.1111/ejn.15740

Vigué-Guix, I., Morís Fernández, L., Torralba Cuello, M., Ruzzoli, M., & Soto-Faraco, S. (2022). Can the occipital alpha-phase speed up visual detection through a real-time EEG-based brain–computer interface (BCI)?. European Journal of Neuroscience, 55(11-12), 3224-3240. Doi:10.1111/ejn.14931

Drew, A., Torralba, M., Ruzzoli, M., Morís Fernández, L., Sabaté, A., Pápai, M.S., & Soto-Faraco, S. (2022). Conflict monitoring and attentional adjustment during binocular rivalry. European Journal of Neuroscience, 55(1), 138-153. Doi:10.1111/ejn.15554

2021

Pavlov, Y.G., Adamian, N., Appelhoff, S., Arvaneh, M., Benwell, C.S.Y., Beste, C., Bland, A.R., Bradford, D.E., Bublatzky, F., Busch, N.A., Clayson, P.E., Cruse, D., Czeszumski, A., Dreber, A., Dumas, G., Ehinger, B., Ganis, G., He, X., Hinojosa, J.A., Huber-Huber, C., Inzlicht, M., Jack, B.N., Johannesson, M., Jones, R., Kalenkovich, E., Kaltwasser, L., Karimi-Rouzbahani, H., Keil, A., König, P., Kouara, L., Kulke, L., Ladouceur, C.D., Langer, N., Liesefeld, H.R., Luque, D., MacNamara, A., Mudrik, L., Muthuraman, M., Neal, L.B., Nilsonne, G., Niso, G., Ocklenburg, S., Oostenveld, R., Pernet, C.R., Pourtois, G., Ruzzoli, M., Sass, S.M., Schaefer, A., Senderecka, M., Snyder, J.S., Tamnes, C.K., Tognoli, E., van Vugt, M.K., Verona, E., Vloeberghs, R., Welke, D., Wessel, J.R., Zakharov, I., & Mushtaq, F. (2021). #EEGManyLabs: Investigating the replicability of influential EEG experiments. Cortex, 144, 213-229. Doi:10.1016/j.cortex.2021.03.013

Cruzat, J., Torralba, M., Ruzzoli, M., Fernández, A., Deco, G., & Soto-Faraco, S. (2021). The phase of Theta oscillations modulates successful memory formation at encoding. Neuropsychologia, 154. Doi:10.1016/j.neuropsychologia.2021.107775

2020

Orpella, J., Ripollés, P., Ruzzoli, M., Amengual, J.L., Callejas, A., Martinez-Alvarez, A., Soto-Faraco, S., & de Diego-Balaguer, R. (2020). Integrating when and what information in the left parietal lobule allows language rule generalization. PLoS Biology, 18(11). Doi:10.1371/journal.pbio.3000895

Ruzzoli, M., McGuinness, A., Fernández, L.M., & Soto-Faraco, S. (2020). From cognitive control to visual incongruity: Conflict detection in surrealistic images. PLoS ONE, 15(6). Doi:10.1371/journal.pone.0224053

2019

Ruzzoli, M., Torralba, M., Morís Fernández, L., & Soto-Faraco, S. (2019). The relevance of alpha phase in human perception. Cortex, 120, 249-268. Doi:10.1016/j.cortex.2019.05.012

Zazio, A., Bortoletto, M., Ruzzoli, M., Miniussi, C., & Veniero, D. (2019). Perceptual and Physiological Consequences of Dark Adaptation: A TMS-EEG Study. Brain Topography, 32(5), 773-782. Doi:10.1007/s10548-019-00715-x

Ikumi, N., Torralba, M., Ruzzoli, M., & Soto-Faraco, S. (2019). The phase of pre-stimulus brain oscillations correlates with cross-modal synchrony perception. European Journal of Neuroscience, 49(2), 150-164. Doi:10.1111/ejn.14186

2018

Castro, L., Soto-Faraco, S., Morís Fernández, L., & Ruzzoli, M. (2018). The breakdown of the Simon effect in cross-modal contexts: EEG evidence. European Journal of Neuroscience, 47(7), 832-844. Doi:10.1111/ejn.13882

2017

Ruzzoli, M., & Soto-Faraco, S. (2017). Modality-switching in the simon task: THE clash of reference frames. Journal of Experimental Psychology: General, 146(10), 1478-1497. Doi:10.1037/xge0000342

Mazzi, C., Savazzi, S., Abrahamyan, A., & Ruzzoli, M. (2017). Reliability of TMS phosphene threshold estimation: Toward a standardized protocol. Brain Stimulation, 10(3), 609-617. Doi:10.1016/j.brs.2017.01.582

2016

Ruzzoli, M., Pirulli, C., Mazza, V., Miniussi, C., & Brignani, D. (2016). The mismatch negativity as an index of cognitive decline for the early detection of Alzheimer's disease. Scientific Reports, 6. Doi:10.1038/srep33167

2015

Campagna, F., Montagnese, S., Schiff, S., Ruzzoli, M., Biancardi, A., Iannizzi, P., Pujatti, P.L., Angeli, P., Gatta, A., Merkel, C., Leandro, G., Mapelli, D., & Amodio, P. (2015). Confounders in the detection of minimal hepatic encephalopathy: A neuropsychological and quantified EEG study. Liver International, 35(5), 1524-1532. Doi:10.1111/liv.12635

2014

Ruzzoli, M., & Soto-Faraco, S. (2014). Alpha stimulation of the human parietal cortex attunes tactile perception to external space. Current Biology, 24(3), 329-332. Doi:10.1016/j.cub.2013.12.029

2013

Brignani, D., Ruzzoli, M., Mauri, P., & Miniussi, C. (2013). Is Transcranial Alternating Current Stimulation Effective in Modulating Brain Oscillations?. PLoS ONE, 8(2). Doi:10.1371/journal.pone.0056589

Miniussi, C., Harris, J.A., & Ruzzoli, M. (2013). Modelling non-invasive brain stimulation in cognitive neuroscience. Neuroscience and Biobehavioral Reviews, 37(8), 1702-1712. Doi:10.1016/j.neubiorev.2013.06.014

2012

Ruzzoli, M., Pirulli, C., Brignani, D., Maioli, C., & Miniussi, C. (2012). Sensory memory during physiological aging indexed by mismatch negativity (MMN). Neurobiology of Aging, 33(3), 625.e21-625.e30. Doi:10.1016/j.neurobiolaging.2011.03.021

2011

Ruzzoli, M., Gori, S., Pavan, A., Pirulli, C., Marzi, C.A., & Miniussi, C. (2011). The neural basis of the Enigma illusion: A transcranial magnetic stimulation study. Neuropsychologia, 49(13), 3648-3655. Doi:10.1016/j.neuropsychologia.2011.09.020

Abrahamyan, A., Clifford, C.W.G., Ruzzoli, M., Phillips, D., Arabzadeh, E., & Harris, J.A. (2011). Accurate and rapid estimation of phosphene thresholds (REPT). PLoS ONE, 6(7). Doi:10.1371/journal.pone.0022342

Ruzzoli, M., Abrahamyan, A., Clifford, C.W.G., Marzi, C.A., Miniussi, C., & Harris, J.A. (2011). The effect of tms on visual motion sensitivity: An increase in neural noise or a decrease in signal strength?. Journal of Neurophysiology, 106(1), 138-143. Doi:10.1152/jn.00746.2010

2010

Ruzzoli, M., Marzi, C.A., & Miniussi, C. (2010). The neural mechanisms of the effects of transcranial magnetic stimulation on perception. Journal of Neurophysiology, 103(6), 2982-2989. Doi:10.1152/jn.01096.2009

Miniussi, C., Ruzzoli, M., & Walsh, V. (2010). The mechanism of transcranial magnetic stimulation in cognition. Cortex, 46(1), 128-130. Doi:10.1016/j.cortex.2009.03.004

2008

Harris, I.M., Benito, C.T., Ruzzoli, M., & Miniussi, C. (2008). Effects of right parietal transcranial magnetic stimulation on object identification and orientation judgments. Journal of Cognitive Neuroscience, 20(5), 916-926. Doi:10.1162/jocn.2008.20513

2024

SpinC: The Motivational Power of Cognitive Conflict

Program: Plan Nacional 2023, PID2023-148910NB-I00
Funding agency: Spanish Ministry
09/2024- 08/2028
Funding: 147.000 €
PI: Manuela Ruzzoli Team member: Drew Jordan McLaughlin

2022

MultiCRCI: MultiModal Cancer Related Cognitive Impairment

Program: Gipuzkoa Next 2022, FA OF 94/2022
Funding agency: Diputación Foral de Gipuzkoa
10/2022- 10/2023
Funding: 148.440 €
PI: Ruzzoli M. co-PI: Molinaro N. collaborators: Paz-Alonso; Carreiras

2021

SweetC: El punto justo del conflicto cognitivo - The 'sweet spot' of Cognitive Conflict

Program: PID2020-114717RA-I00
Funding agency: Spanish Ministry
09/2021- 08/2024
Funding: 88.330 €
PI: Manuela Ruzzoli; Research Team: Alexia Antzaka; Work Team: Marc Vives, Salvador Soto, Aoife McGuinness

Ramon y Cajal Tenure Track (01/06/2021 - 31/05/2026), Ministero de Ciencia y Innovacion. BCBL, San Sebastian.

Marie Sklodowska-Curie Research Fellow (01/2019 - 05/2021), European Commission. University of Glasgow, Scotland.

Juan de la Cierva (01/2014 - 12/2016), Ministerio de la Ciencia y Innovacion. University Pompeu Fabra, Spain.

2024

Ciardo, E., González-Pérez, M.F., Paz-Alonso, P.M., Carreiras, M., & Ruzzoli, M. (2024). The neural markers of mild cognitive impairment in breast cancer patients: a multimodal approach to detect, predict and monitor. Poster presentation at Sociedad Española de Psicología Experimental (SEPEX) 2024. Almeria, Spain.