Cesar Caballero-Gaudes

Research

Group Leader - Ikerbasque Research Associate 2024-2029 (Former Ramon y Cajal Fellow since 2019-2024)

Keywords: functional and structural neuroimaging; magnetic resonance imaging (MRI) physics and sequence development; BOLD fMRI: data analysis, signal processing methods, connectivity, and physiological basis; inverse problems and reconstruction; pattern recognition and machine learning.

Research group: Signal Processing in Neuroimaging

c.caballero@bcbl.eu

+34 943 309 300 Ext.: 207

In press

Blanco, B., Molnar, M., Arrieta, I., Caballero-Gaudes, C., & Carreiras, M. (In press). Functional Brain Adaptations During Speech Processing in 4-Month-Old Bilingual Infants. Developmental Science. Doi:10.1111/desc.13572

2024

Lynch, C.J., Elbau, I.G., Ng, T., Ayaz, A., Zhu, S., Wolk, D., Manfredi, N., Johnson, M., Chang, M., Chou, J., Summerville, I., Ho, C., Lueckel, M., Bukhari, H., Buchanan, D., Victoria, L.W., Solomonov, N., Goldwaser, E., Moia, S., Caballero-Gaudes, C., Downar, J., Vila-Rodriguez, F., Daskalakis, Z.J., Blumberger, D.M., Kay, K., Aloysi, A., Gordon, E.M., Bhati, M.T., Williams, N., Power, J.D., Zebley, B., Grosenick, L., Gunning, F.M., & Liston, C. (2024). Frontostriatal salience network expansion in individuals in depression. Nature, 633(8030), 624-633. Doi:10.1038/s41586-024-07805-2

Uruñuela, E., Gonzalez-Castillo, J., Zheng, C., Bandettini, P., & Caballero-Gaudes, C. (2024). Whole-brain multivariate hemodynamic deconvolution for functional MRI with stability selection. Medical Image Analysis, 91. Doi:10.1016/j.media.2023.103010

2023

Delgado-Alvarado, M., Ferrer-Gallardo, V.J., Paz-Alonso, P.M., Caballero-Gaudes, C., & Rodríguez-Oroz, M.C. (2023). Interactions between functional networks in Parkinson's disease mild cognitive impairment. Scientific Reports, 13(1). Doi:10.1038/s41598-023-46991-3

Zvolanek, K.M., Moia, S., Dean, J.N., Stickland, R.C., Caballero-Gaudes, C., & Bright, M.G. (2023). Comparing end-tidal CO<inf>2</inf>, respiration volume per time (RVT), and average gray matter signal for mapping cerebrovascular reactivity amplitude and delay with breath-hold task BOLD fMRI. NeuroImage, 272. Doi:10.1016/j.neuroimage.2023.120038

2022

Stickland, R.C., Zvolanek, K.M., Moia, S., Caballero-Gaudes, C., & Bright, M.G. (2022). Lag-Optimized Blood Oxygenation Level Dependent Cerebrovascular Reactivity Estimates Derived From Breathing Task Data Have a Stronger Relationship With Baseline Cerebral Blood Flow. Frontiers in Neuroscience, 16. Doi:10.3389/fnins.2022.910025

Bouziane, I., Das, M., Friston, K.J., Caballero-Gaudes, C., & Ray, D. (2022). Enhanced top-down sensorimotor processing in somatic anxiety. Translational Psychiatry, 12(1). Doi:10.1038/s41398-022-02061-2

Basaia, S., Agosta, F., Diez, I., Bueichekú, E., d'Oleire Uquillas, F., Delgado-Alvarado, M., Caballero-Gaudes, C., Rodriguez-Oroz, M.C., Stojkovic, T., Kostic, V.S., Filippi, M., & Sepulcre, J. (2022). Neurogenetic traits outline vulnerability to cortical disruption in Parkinson's disease. NeuroImage: Clinical, 33. Doi:10.1016/j.nicl.2022.102941

2021

Guediche, S., de Bruin, A., Caballero-Gaudes, C., Baart, M., & Samuel, A.G. (2021). Second-language word recognition in noise: Interdependent neuromodulatory effects of semantic context and crosslinguistic interactions driven by word form similarity. NeuroImage, 237. Doi:10.1016/j.neuroimage.2021.118168

Moia, S., Termenon, M., Uruñuela, E., Chen, G., Stickland, R.C., Bright, M.G., & Caballero-Gaudes, C. (2021). ICA-based denoising strategies in breath-hold induced cerebrovascular reactivity mapping with multi echo BOLD fMRI. NeuroImage, 233. Doi:10.1016/j.neuroimage.2021.117914

Stickland, R.C., Zvolanek, K.M., Moia, S., Ayyagari, A., Caballero-Gaudes, C., & Bright, M.G. (2021). A practical modification to a resting state fMRI protocol for improved characterization of cerebrovascular function. NeuroImage, 239. Doi:10.1016/j.neuroimage.2021.118306

Gau, R., Noble, S., Heuer, K., Bottenhorn, K.L., Bilgin, I.P., Yang, Y.F., Huntenburg, J.M., Bayer, J.M.M., Bethlehem, R.A.I., Rhoads, S.A., Vogelbacher, C., Borghesani, V., Levitis, E., Wang, H.T., Van Den Bossche, S., Kobeleva, X., Legarreta, J.H., Guay, S., Atay, S.M., Varoquaux, G.P., Huijser, D.C., Sandström, M.S., Herholz, P., Nastase, S.A., Badhwar, A.P., Dumas, G., Schwab, S., Moia, S., Dayan, M., Bassil, Y., Brooks, P.P., Mancini, M., Shine, J.M., O'Connor, D., Xie, X., Poggiali, D., Friedrich, P., Heinsfeld, A.S., Riedl, L., Toro, R., Caballero-Gaudes, C., Eklund, A., Garner, K.G., Nolan, C.R., Demeter, D.V., Barrios, F.A., Merchant, J.S., McDevitt, E.A., Oostenveld, R., Craddock, R.C., Rokem, A., Doyle, A., Ghosh, S.S., Nikolaidis, A., Stanley, O.W., Uruñuela, E., Anousheh, N., Arnatkeviciute, A., Auzias, G., Bachar, D., Bannier, E., Basanisi, R., Basavaraj, A., Bedini, M., Bellec, P., Benn, R.A., Berluti, K., Bollmann, S., Bollmann, S., Bradley, C., Brown, J., Buchweitz, A., Callahan, P., Chan, M.Y., Chandio, B.Q., Cheng, T., Chopra, S., Chung, A.W., Close, T.G., Combrisson, E., Cona, G., Constable, R.T., Cury, C., Dadi, K., Damasceno, P.F., Das, S., De Vico Fallani, F., DeStasio, K., Dickie, E.W., Dorfschmidt, L., Duff, E.P., DuPre, E., Dziura, S., Esper, N.B., Esteban, O., Fadnavis, S., Flandin, G., Flannery, J.E., Flournoy, J., & Forkel, S.J. (2021). Brainhack: Developing a culture of open, inclusive, community-driven neuroscience. Neuron, 109(11), 1769-1775. Doi:10.1016/j.neuron.2021.04.001

Blanco, B., Molnar, M., Carreiras, M., Collins-Jones, L.H., Vidal, E., Cooper, R.J., & Caballero-Gaudes, C. (2021). Group-level cortical functional connectivity patterns using fNIRS: assessing the effect of bilingualism in young infants. Neurophotonics, 8(2). Doi:10.1117/1.NPh.8.2.025011

Heunis, S., Breeuwer, M., Caballero-Gaudes, C., Hellrung, L., Huijbers, W., Jansen, J.F., Lamerichs, R., Zinger, S., & Aldenkamp, A.P. (2021). The effects of multi-echo fMRI combination and rapid T<inf>2</inf>*-mapping on offline and real-time BOLD sensitivity. NeuroImage, 238. Doi:10.1016/j.neuroimage.2021.118244

Urunuela, E., Moia, S., & Caballero-Gaudes, C. (2021). A low rank and sparse paradigm free mapping algorithm for deconvolution of FMRI data. Proceedings - International Symposium on Biomedical Imaging, 2021-April, 1726-1729. Doi:10.1109/ISBI48211.2021.9433821

2020

Correia, J.M., Caballero-Gaudes, C., Guediche, S., & Carreiras, M. (2020). Phonatory and articulatory representations of speech production in cortical and subcortical fMRI responses. Scientific Reports, 10(1). Doi:10.1038/s41598-020-61435-y

Bolton, T.A.W., Urunuela, E., Tian, Y., Zalesky, A., Caballero-Gaudes, C., & Van De Ville, D. (2020). Sparse coupled logistic regression to estimate co-activation and modulatory influences of brain regions. Journal of Neural Engineering, 17(6). Doi:10.1088/1741-2552/aba55e

Lee, C.W., Blanco, B., Dempsey, L., Chalia, M., Hebden, J.C., Caballero-Gaudes, C., Austin, T., & Cooper, R.J. (2020). Sleep State Modulates Resting-State Functional Connectivity in Neonates. Frontiers in Neuroscience, 14. Doi:10.3389/fnins.2020.00347

Bolton, T.A.W., Kebets, V., Glerean, E., Zöller, D., Li, J., Yeo, B.T.T., Caballero-Gaudes, C., & Van De Ville, D. (2020). Agito ergo sum: Correlates of spatio-temporal motion characteristics during fMRI. NeuroImage, 209. Doi:10.1016/j.neuroimage.2019.116433

Moia, S., Stickland, R.C., Ayyagari, A., Termenon, M., Caballero-Gaudes, C., & Bright, M.G. (2020). Voxelwise optimization of hemodynamic lags to improve regional CVR estimates in breath-hold fMRI. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2020-July, 1489-1492. Doi:10.1109/EMBC44109.2020.9176225

Urunuela, E., Jones, S., Crawford, A., Shin, W., Oh, S., Lowe, M., & Caballero-Gaudes, C. (2020). Stability-Based Sparse Paradigm Free Mapping Algorithm for Deconvolution of Functional MRI Data. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2020-July, 1092-1095. Doi:10.1109/EMBC44109.2020.9176137

Heunis, S., Lamerichs, R., Zinger, S., Caballero-Gaudes, C., Jansen, J.F.A., Aldenkamp, B., & Breeuwer, M. (2020). Quality and denoising in real-time functional magnetic resonance imaging neurofeedback: A methods review. Human Brain Mapping, 41(12), 3439-3467. Doi:10.1002/hbm.25010

2019

Caballero-Gaudes, C., Moia, S., Panwar, P., Bandettini, P.A., & Gonzalez-Castillo, J. (2019). A deconvolution algorithm for multi-echo functional MRI: Multi-echo Sparse Paradigm Free Mapping. NeuroImage, 202. Doi:10.1016/j.neuroimage.2019.116081

Gonzalez-Castillo, J., Caballero-Gaudes, C., Topolski, N., Handwerker, D.A., Pereira, F., & Bandettini, P.A. (2019). Imaging the spontaneous flow of thought: Distinct periods of cognition contribute to dynamic functional connectivity during rest. NeuroImage, 202. Doi:10.1016/j.neuroimage.2019.116129

Bastarrika-Iriarte, A., & Caballero-Gaudes, C. (2019). Closing eyes during auditory memory retrieval modulates alpha rhythm but does not alter tau rhythm. NeuroImage, 197, 60-68. Doi:10.1016/j.neuroimage.2019.04.053

2018

Iglesias, J.E., Insausti, R., Lerma-Usabiaga, G., Bocchetta, M., Van Leemput, K., Greve, D.N., van der Kouwe, A., Fischl, B., Caballero-Gaudes, C., & Paz-Alonso, P.M. (2018). A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology. NeuroImage, 183, 314-326. Doi:10.1016/j.neuroimage.2018.08.012

Paz-Alonso, P.M., Oliver, M., Lerma-Usabiaga, G., Caballero-Gaudes, C., Quiñones, I., Suárez-Coalla, P., Duñabeitia, J.A., Cuetos, F., & Carreiras, M. (2018). Neural correlates of phonological, orthographic and semantic reading processing in dyslexia. NeuroImage: Clinical, 20, 433-447. Doi:10.1016/j.nicl.2018.08.018

Rosenthal, C.R., Mallik, I., Caballero-Gaudes, C., Sereno, M.I., & Soto, D. (2018). Learning of goal-relevant and -irrelevant complex visual sequences in human V1. NeuroImage, 179, 215-224. Doi:10.1016/j.neuroimage.2018.06.023

Caballero-Gaudes, C., Moia, S., Bandettini, P.A., & Gonzalez-Castillo, J. (2018). Quantitative deconvolution of fmri data with multi-echo sparse paradigm free mapping. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 11072 LNCS, 311-319. Doi:10.1007/978-3-030-00931-1_36

Gaudes, C.C., Bandettini, P.A., & Gonzalez-Castillo, J. (2018). A temporal deconvolution algorithm for multiecho functional MRI. Proceedings - International Symposium on Biomedical Imaging, 2018-April, 608-611. Doi:10.1109/ISBI.2018.8363649

Blanco, B., Molnar, M., & Caballero-Gaudes, C. (2018). Effect of prewhitening in resting-state functional near-infrared spectroscopy data. Neurophotonics, 5(4). Doi:10.1117/1.NPh.5.4.040401

2017

Tan, F.M., Caballero-Gaudes, C., Mullinger, K.J., Cho, S.Y., Zhang, Y., Dryden, I.L., Francis, S.T., & Gowland, P.A. (2017). Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates. Human Brain Mapping, 38(11), 5778-5794. Doi:10.1002/hbm.23767

Caballero-Gaudes, C., & Reynolds, R.C. (2017). Methods for cleaning the BOLD fMRI signal. NeuroImage, 154, 128-149. Doi:10.1016/j.neuroimage.2016.12.018

Keilholz, S., Caballero-Gaudes, C., Bandettini, P., Deco, G., & Calhoun, V. (2017). Time-Resolved Resting-State Functional Magnetic Resonance Imaging Analysis: Current Status, Challenges, and New Directions. Brain Connectivity, 7(8), 465-481. Doi:10.1089/brain.2017.0543

2016

Gonzalez-Castillo, J., Panwar, P., Buchanan, L.C., Caballero-Gaudes, C., Handwerker, D.A., Jangraw, D.C., Zachariou, V., Inati, S., Roopchansingh, V., Derbyshire, J.A., & Bandettini, P.A. (2016). Evaluation of multi-echo ICA denoising for task based fMRI studies: Block designs, rapid event-related designs, and cardiac-gated fMRI. NeuroImage, 141, 452-468. Doi:10.1016/j.neuroimage.2016.07.049

Iglesias, J.E., Paz-Alonso, P., Lerma-Usabiaga, G., Insausti, R., Miller, K., & Caballero-Gaudes, C. (2016). Simultaneous Bayesian correction of slab boundary artifacts and bias field for high resolution ex vivo MRI. Proceedings - International Symposium on Biomedical Imaging, 2016-June, 1384-1387. Doi:10.1109/ISBI.2016.7493525

2015

Allan, T.W., Francis, S.T., Caballero-Gaudes, C., Morris, P.G., Liddle, E.B., Liddle, P.F., Brookes, M.J., & Gowland, P.A. (2015). Functional connectivity in MRI is driven by spontaneous BOLD events. PLoS ONE, 10(4). Doi:10.1371/journal.pone.0124577

2013

Petridou, N., Gaudes, C.C., Dryden, I.L., Francis, S.T., & Gowland, P.A. (2013). Periods of rest in fMRI contain individual spontaneous events which are related to slowly fluctuating spontaneous activity. Human Brain Mapping, 34(6), 1319-1329. Doi:10.1002/hbm.21513

Karahanoǧlu, F.I., Caballero-Gaudes, C., Lazeyras, F., & Van De Ville, D. (2013). Total activation: FMRI deconvolution through spatio-temporal regularization. NeuroImage, 73, 121-134. Doi:10.1016/j.neuroimage.2013.01.067

Caballero Gaudes, C., Petridou, N., Francis, S.T., Dryden, I.L., & Gowland, P.A. (2013). Paradigm free mapping with sparse regression automatically detects single-trial functional magnetic resonance imaging blood oxygenation level dependent responses. Human Brain Mapping, 34(3), 501-518. Doi:10.1002/hbm.21452

Caballero-Gaudes, C., Van de Ville, D., Grouiller, F., Thornton, R., Lemieux, L., Seeck, M., Lazeyras, F., & Vulliemoz, S. (2013). Mapping interictal epileptic discharges using mutual information between concurrent EEG and fMRI. NeuroImage, 68, 248-262. Doi:10.1016/j.neuroimage.2012.12.011

Karahanoglu, F.I., Grouiller, F., Gaudes, C.C., Seeck, M., Vulliemoz, S., & Van De Ville, D. (2013). Spatial mapping of interictal epileptic discharges in fMRI with total activation. Proceedings - International Symposium on Biomedical Imaging, 1500-1503. Doi:10.1109/ISBI.2013.6556819

2012

Gaudes, C.C., Karahanoǧlu, F.I., Lazeyras, F., & Van De Ville, D. (2012). Structured sparse deconvolution for paradigm free mapping of functional MRI data. Proceedings - International Symposium on Biomedical Imaging, 322-325. Doi:10.1109/ISBI.2012.6235549

2011

Gaudes, C.C., Petridou, N., Dryden, I.L., Bai, L., Francis, S.T., & Gowland, P.A. (2011). Detection and characterization of single-trial fMRI bold responses: Paradigm free mapping. Human Brain Mapping, 32(9), 1400-1418. Doi:10.1002/hbm.21116

Caballero Gaudes, C., Van De Ville, D., Petridou, N., Lazeyras, F., & Gowland, P. (2011). Paradigm-free mapping with morphological component analysis: Getting most out of fMRI data. Proceedings of SPIE - The International Society for Optical Engineering, 8138. Doi:10.1117/12.893920

2007

Gaudes, C.C., Santamaría, I., Vía, J., Gómez, E.M., & Sesé Paules, T. (2007). Robust array beamforming with sidelobe control using support vector machines. IEEE Transactions on Signal Processing, 55(2), 574-584. Doi:10.1109/TSP.2006.885720

2006

Gaudes, C.C., & Masgrau, E. (2006). Bounds on capacity over Gaussian MIMO multiaccess channels with channel state information mismatch. ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings, 4.

2004

Gaudes, C.C., Vía, J., & Santamaría, I. (2004). An IRWLS procedure for robust beamforming with sidelobe control. 2004 Sensor Array and Multichannel Signal Processing Workshop, 342-346.

Gaudes, C.C., Vía, J., & Santamaría, I. (2004). Robust array beamforming with sidelobe control using support vector machines. IEEE Workshop on Signal Processing Advances in Wireless Communications, SPAWC, 258-262.

Santamaría, I., Vía, J., & Gaudes, C.C. (2004). Robust blind identification of SIMO channels: A support vector regression approach. ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings, 5.

2003

Caballero Gaudes, C., Valkama, M., & Renfors, M. (2003). A novel frequency synthesizer concept for wireless communications. Proceedings - IEEE International Symposium on Circuits and Systems, 2.

2002

Caballero Gaudes, C., Valkama, M., Renfors, M., & Ajanki, J. (2002). Fast frequency synthesizer concept based on digital tuning and I/Q signal processing. International Conference on Digital Signal Processing, DSP, 2, 1317-1320. Doi:10.1109/ICDSP.2002.1028336

2024

GlioPrecision: Precision functional and cerebrovascular reactivity mapping of the individual healthy brain and gliomas

Program: Plan Nacional 2023, PID2023-149410OB-I00
Funding agency: Spanish Ministry
09/2024- 08/2027
Funding: 183.500 €
PI: César Caballero-Gaudes

2020

qRSFMRI: Estudio cuantitativo de las fluctuaciones en la conectividad funcional y actividad cerebral en reposo con imagen de resonancia magnética funcional de ASL y multieco BOLD

Program: PID2019-105520GB-I00
Funding agency: Spanish Ministry
06/2020- 05/2023
Funding: 47.432 €
PI: Cesar Caballero-Gaudés Team member: Maite Termenon

2019

Quantifying the dynamics of spontaneous brain fluctuations with calibrated functional magnetic resonance imaging techniques

Program: PIBA_2019_1_0104
Funding agency: Basque Government
09/2019- 09/2021
Funding: 48.912 €
PI: Cesar Caballero

2014

Neuroimagen Multimodal de las Redes de Oscilación en Memoria de Trabajo

Program: PSI2013-42343-P
Funding agency: Spanish Ministry
01/2014- 12/2016
Funding: 50.000 €
PI: Cesar Caballero

Ramon y Cajal Fellow (02/2019 - 01/2024), Spanish Ministry. BCBL - Basque Center on Cognition, Brain & Language, Donostia-San Sebastián.

Juan de la Cierva Incorporación fellowship (11/2016 - 10/2018), Spanish Ministry. BCBL-Basque Center on Cognition,Brain and Language, Donostia-San Sebastián. Spain.

In progress

Alteraciones en la conectividad tálamocortical en deterioro cognitivo leve en la enfermedad de Parkinson University of the Basque Country, UPV/EHU (2020 - 2024)

Desarrollo de algoritmos de deconvolucio?n multivariados para resonancia magnetica funcional. University of the Basque Country, UPV/EHU (2019 - 2024)

Advanced spatio-temporal deconvolution algorithms to investigate brain function with functional magnetic resonance imaging (fMRI) University of the Basque Country, UPV/EHU (2017 - 2020)

Influence of bilingual exposure in the developing human brain University of the Basque Country, UPV/EHU (2015 - 2020)

Defended

Changes in brain activity during language learning in adults measured by magnetoencephalography University of the Basque Country, UPV/EHU (2013 - 2017)

EEG and MEG evidence of a predominant number code in bilinguals and its significance for developmental dyscalculia University of the Basque Country, UPV/EHU (2013 - 2017)

2023

Vicente Ferrer-Gallardo, Eneko Uruñuela, César Caballero-Gaudes (2023). Blind estimation of neuronal-related activity in fMRI informed by co-fluctuations of brain regions Author and presenter Organization of the human brain mapping society annual meeting (OHBM 2022)

2022

Ferrer-Gallardo, V., Esteban-Peñalba, T., Caballero-Gaudes, C., & Paz-Alonso, P.M. (2022). Thalamic volume and lateralization on Parkinson Disease associated with cognitive and motor deficits. Poster presentation at Organization for Human Brain Mapping (OHBM) 2022 Meeting, Glasgow, United Kingdom.

2013

Paz-Alonso, P.M., Quiñones, I., Caballero, C., Oliver, M., Suarez-Coalla, M.P., Cuetos, F., Duñabeitia, J.A., & Carreiras, M. (2013). Neural correlates of the ran in typical and atypical developing readers. Poster presentation at the International Workshop on Reading and Developmental Dyslexia (IWORDD) 2013, Donostia, Spain.